Adverse drug events (ADEs) associated with anticoagulants can be reduced by implementing recognized safe practices in high-risk areas, redesigning care processes, partnering with patients and families and maximizing communications within and across the care continuum. This toolkit outlines common risks and suggested safe practices and resources to reduce or eliminate risks that could lead to adverse drug events from anticoagulants such as unfractionated heparin, low molecular weight heparins and warfarin.